Topic: cell-intrinsic bursting

The evolution of the Na+/K+-ATPase in ancestral methanogenic archaea also lay the foundation for the energetics of energy-intensive signaling tissues like the metazoan nervous systems billions of years later. The electrogenic property of this pump, which originally evolved to balance intra- and extracellular osmotic pressures, seems a useful preadaptation for certain encoding paradigms, cell-intrinsic bursting dynamics, and accelerated ion homeostasis. We show that for nerve and muscle cells that need to be tonically active for long stretches of time (on the order of minutes to hours), the ele