Topic: cellular degradation pathways

Corpora amylacea (CAs) are a type of polyglucosan bodies that are generally found in a variety of organs during aging, including the human brain. While CAs in the human brain mainly consist of abnormal glycogen molecules, they also contain a set of proteins including Ubiquitin and p62, which are usually involved in cellular degradation pathways. The abundance of CAs is strikingly increased in neurodegenerative conditions such as Alzheimer’s disease (AD), suggesting that the occurrence of CAs might either be a protective mechanism or a co-morbidity in the aging human brain. To understand the fo