Modulation of vagus nerve activity during spontaneous recurrent seizures in the kainic acid model of temporal lobe epilepsy
Elena Acedo Reina, Enrique Germany Morrison, Antoine Nonclercq, Riëm El Tahry · FENS Forum 2024
Seizures produce autonomic symptoms, mainly sympathetic but also parasympathetic in origin. As the vagus nerve (VN) is the main parasympathetic output, the aims of the project is to characterize VN activity during seizures for potential future development closed-loop VNS.Spontaneous seizures were pharmacologically induced in two male Wistar rats (380±14g) by IP kainic acid systemic administration. Surgeries were performed three months after status induction. Three epidural electrodes were implanted for EEG recording. A tripolar Micro-cuff electrode was placed around the left cervical VN to rec
ePoster · Neuroscience