Topic: Ceramides

Alcohol abuse and depression are severe comorbid psychiatric illnesses often accompanied by peripheral disorders, such as osteoporosis. Crucial members of biological membranes, ceramides, contribute to the pathogenesis of single disorders, while role of the ceramide system in their comorbidities remains unclear. We observed the specific contribution of an enzyme of the ceramide metabolism, neutral sphingomyelinase (NSM), in the comorbidity of alcohol use disorder, anxiety/depression, and osteoporosis. A genetic association analysis performed on 456,693 participants showed an association betwee