ePoster · Computational Neuroscience
Modeling the autistic cerebellum: propagation of granule cells alteration through the granular layer microcircuit
Danilo Benozzo, Alessio Marta, Robin De Schepper, Martina Rizza, Stefano Masoli, Egidio D'Angelo, Claudia Casellato · Bernstein Conference 2024
Modeling brain dynamics requires addressing processes that span different temporal and spatial scales [1]. This is crucial, when studying phenomena at the circuit level that are consequences of pharmacological or pathological alterations occurring at the single-cell level, such as changes in ionic or synaptic currents. Here, our aim is to study how single-cell dynamics interact with and affect circuit dynamics in a mouse model of autism (IB2 knock-out, KO), within the context of the cerebellar cortical microcircuit. In this work, we used a bottom-up approach: the microcircuit connectivity was