Topic: cerebellar fastigial nucleus

“Cerebellar Mutism” is a challenging problem after resection of pediatric tumors in cerebellar midline structures, with the nucleus fastigii regarded relevant. Although the symptoms are mainly transient, children often have long-term social and cognitive deficits. We already showed that juvenile rats with lesions of the cerebellar fastigial nucleus show behavioral deficits and altered neural activity in the medial prefrontal cortex (mPFC). In our study, we recorded prefrontal neural activity during behavioral testing for attention and decision-making. Rats (lesion [n=9], sham-lesion [n=6], naï