Topic: cerebellar granule cell

The cerebellum has a well-established role in fine motor control and motor learning. In the cerebellar cortex, the first stage of information processing takes places at synapses between mossy fiber (MF) and cerebellar granule cell (GC) synapses, where synaptic transmission occurs at ultra-high frequencies (up to kHz). MF presynaptic machinery is capable of releasing glutamate at such extreme frequencies but the molecular determinants and ultrastructural organization underlying this presynaptic efficiency have yet to be elucidated. In several synapse types, the actin cytoskeleton, which is dyna