Topic: cerebellar hemispheres

Recent evidence suggests that the cerebellar hemispheres are in a unique position to contribute to motor planning via cortico-cerebellar loops. However, it is unknown how the dynamics of preparatory activity relate to the functional parcellation of the cerebellar cortex. We used mesoscale widefield calcium imaging to study molecular layer interneuron and Purkinje cell dendritic Ca2+ activity in Simplex, Crus I and Crus II during a targeted lick-interception task. We identified independent spatial sources of Ca2+ activity in interneurons and Purkinje cell dendrites using non-negative matrix fac