Altered excitatory/inhibitory balance in the prefrontal cortex of the IB2 KO mouse model of autism: From neuronal excitability to cerebellar modulation in vivo
Eleonora Pali, Danila Di Domenico, Maria Conforti, Ileana Montagna, Teresa Soda, Simona Tritto, Egidio D'Angelo, Francesca Prestori, Lisa Mapelli · FENS Forum 2024
Autism spectrum disorder (ASD) is a pervasive neurodevelopmental condition with heterogeneous phenotype. Here, we investigated prefrontal cortex (PFC) alterations and cerebellum-PFC connectivity in the IB2 KO mouse model of ASD. Significant alterations in signal processing and plasticity have been reported in the cerebellar granular layer of IB2 KO mice, confirming the crucial cerebellar involvement in ASD pathophysiology. Given the PFC renowned role in ASD and its functional connections with the cerebellum, we explored the prelimbic cortex (PrL) microcircuitry in IB2 KO and WT mice at differe
ePoster · Neuroscience