Investigating the development of the GABAergic system using human brain organoids
Chloe Hall, Sudena Wang, Michael K.E. Schäfer, Thomas Mittmann · FENS Forum 2024
Organoids derived from human stem cells present enormous potential to investigate aspects of human brain development. In this study, we hypothesised that brain organoids represent a suitable method for studying the shift in GABAergic transmission, from excitatory to inhibitory, during development. As several anaesthetics act via GABA receptors, we aimed to investigate how the anaesthetic propofol, known to be a GABA-A receptor agonist, may affect neuronal transmission in cerebral brain organoids at different developmental stages. Organoids cultivated from human embryonic stem cells (H1-ESC), w
ePoster · Neuroscience