Cellular and molecular footprint of aging in a defined neuronal network encoding associative memory
István Fodor, Bence Gálik, Péter Urbán, János Schmidt, Réka Svigruha, György Kemenes, Ildikó Kemenes, Zsolt Pirger · FENS Forum 2024
Due to the complexity of CNS, studying the aging processes at the level of neural circuits and individually identified neurons is not an easy task in vertebrates, hence aging research heavily relies on invertebrate models. One such model is the great pond snail (Lymnaea stagnalis), which has been used extensively to study cognitive aging.We made the neuronal transcriptome assembly of Lymnaea and identified several evolutionarily conserved homolog sequences to genes involved in aging, age-related memory impairment, and neurodegenerative diseases of vertebrates including humans. Using young (3-4
ePoster · Neuroscience