Comprehensive characterization of PS19 tauopathy transgenic mouse model: Studying Tau's role in Alzheimer's disease and preclinical model suitability
Antía Custodia Malvido, Marta Aramburu-Núñez, Noemí Gómez-Lado, Mariña Rodríguez-Arrizabalaga, Mónica Castro-Mosquera, Manuel Debasa-Mouce, Juan Manuel Pías-Peleteiro, Javier Camino-Castiñeiras, José Manuel Aldrey, Daniel Romaus-Sanjurjo, Pablo Aguiar, Alberto Ouro, Tomás Sobrino · FENS Forum 2024
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, characterized by the accumulation of Aβ and Tau proteins. While many animal models primarily focus on Aβ, this study centers on characterizing a tauopathy model, the PS19 model (B6;C3-Tg(Prnp-MAPT*P301S)PS19Vle/J), to explore the pathological role of tau in AD.36 PS19 and 24 non-carrier mice (NCAR) were followed from 12 to 50 weeks, assessing locomotor, behavior, and memory activity, neurodegeneration, neuroinflammation, blood-brain barrier (BBB) integrity, cerebral glucose metabolism, and neurodegenerative progression
ePoster · Neuroscience