Neuroprotective effects of MK801 against cerebral ischemia-reperfusion injury
Zahra Yaghoobi, Esmail Riahi, Mohsen Parviz, Saereh Hosseindoost, Fardin Sehati, Saeid Ataei, Ghorbangol Ashabi · FENS Forum 2024
During Cerebral ischemia/reperfusion injury (I/RI), NMDA receptor activity increases, leading to an excessive entry of sodium and calcium, which damages neurons. Therefore, deletion of NMDA receptor subunits may reduce cell death induced by acute brain injury. MK801 is a non-competitive NMDA receptor antagonist that can block NMDA ion channels. In this experimental study, Wistar rats were divided into 6 groups:Sham, I/R, I/R+NMDA (0.5 mg/kg, IV), I/R+MK801 (0.5 mg/kg, IV), I/R+NMDA+ electrophysiology, and I/R+MK801+ electrophysiology. The acute cerebral ischemic injury was induced in rats by o
ePoster · Neuroscience