Topic: cerebral parenchyma

The dysfunction or disruption of the blood-brain barrier (BBB) has been associated with the development and progression of many neurodegenerative diseases, such as Alzheimer’s Disease (AD). However, most in vitro BBB models are static, complicating the understanding of disease pathophysiology. With that, our study aims to develop a microfluidic device to better study the relationship between neurodegenerative diseases and the BBB in vitro. The device, printed using polydimethylsiloxane, includes a compartment for a hydrogel containing neurons and astrocytes to mimic cerebral parenchyma and a m