Adiponectin deficiency exacerbates cerebrovascular dysfunction in 5xFAD mouse model of Alzheimer’s disease
Wenying Zou, Leung-Wah Yick, Zifei Zhang, Jason Shing-Cheong Kwan, Koon-Ho Chan · FENS Forum 2024
Cerebrovascular damage and dysfunction have been suggested to be closely related to pathophysiology of Alzheimer's disease (AD). The effect of adiponectin (APN), an adipocyte-secreted hormone, on the risk and progression of AD patients remains unclear. APN has been demonstrated to play a protective role in peripheral vasculature, while little is known about its impact on cerebrovascular dysfunction in AD. In this study, we examined the cerebrovascular integrity of wildtype, 5xFAD, APN knockout (APN-/-), and APN-deficient 5xFAD (5xFAD;APN-/-) mice in terms of blood-brain barrier (BBB) permeabil
ePoster · Neuroscience