Comprehensive characterization of cerebrovascular oxygenation dynamics in awake mice using high-resolution photoacoustic imaging
Juri Aparicio Arias, Philippe Trochet, Chrystel Lafont, Patrice Mollard, Dieter Fuchs, Pierre Sicard · FENS Forum 2024
Aims: Investigating cerebral oxygen saturation dynamics in awake animal models presents significant technical challenges. We introduce a novel approach utilizing high-resolution ultrasound photoacoustic (PA) imaging to monitor deep cerebrovascular oxygen saturation dynamics in awake mice.Methods: Swiss male and female mice (n=5-6) were immobilized using the Mobile HomeCage (Neurotar, Finland) floating platform. We used high-resolution ultrasound associated with PA imaging (VevoLAZR-X, Visualsonics) to track neurovascular oxygenation trajectories in awake mice in response to 2% isoflurane or do
ePoster · Neuroscience