Unveiling cortical microvascular dysfunction and neurodegeneration mechanisms in experimental autoimmune encephalomyelitis
Mohammadreza Yousefi, Ayşe Özkan, Yiğit Uysallı, Kaan Kutay Özmen, Dila Atak, Mina Mamipour, Nazan Akkaya, Morteza Heidarzadeh, Şefik Evren Erdener, Alper Kiraz, Yasemin Gürsoy Özdemir, Atay Vural · FENS Forum 2024
The mechanisms underlying neurodegeneration in multiple sclerosis (MS) remain incompletely understood. In this study, we aimed to investigate the role of vascular dysfunction in cortical neurodegeneration using a chronic cranial window model of experimental autoimmune encephalomyelitis (EAE) in mice.Following the establishment of chronic cranial window and induction of EAE with MOG peptides in C57BL6/J mice, we assessed cerebrovascular reactivity (CVR) using both laser speckle contrast imaging (LSCI) and optical signal imaging (IOSI) in awake animals, with stimuli including air puff to the whi
ePoster · Neuroscience