Seminar · Developmental Neuroscience
Molecular controls over corticospinal neuron axon branching at specific spinal segments
Yasuhiro Itoh · Harvard
Wed, Oct 28, 2020 · 09:00 UTC
Corticospinal neurons (CSN) are the cortical projection neurons that innervate the spinal cord and some brainstem targets with segmental precision to control voluntary movement of specific functional motor groups, limb sections, or individual digits, yet molecular regulation over CSN segmental target specificity is essentially unknown. CSN subpopulations exhibit striking axon targeting specificity from development into maturity: Evolutionarily newer rostrolateral CSN exclusively innervate bulbar-cervical targets (CSNBC-lat), while evolutionarily older caudomedial CSN (CSNmed) are more heteroge