The novel astrocytic marker CETN2 expression in Alzheimer’s disease
Maria Teresa Dell'Anno, Elisa Degl'Innocenti, Francesco Olimpico, Francesco Finamore, Emanuele Poloni, Valentina Medici, Liam Andrew Mc Donnell · FENS Forum 2024
CETN2 is a centrosomal, calcium-binding protein implicated in mitosis and DNA repair best known for its expression in photoreceptors and ciliated cells. Here, we took advantage of a culture of human neuroepithelial stem (NES) to determine its expression in other cell types of the nervous tissue. We confirmed CETN2 centrosomal location in proliferating NES cells, and pointed out its relocation along with the differentiation process describing its cytoplasmic distribution in human astrocytes, while being absent in all other cell types. Next, we questioned about CETN2 role in pathologies in which
ePoster · Neuroscience