Disentangling error signals in Purkinje cell dendritic activity from their pre-synaptic climbing fiber inputs during sensory association and adaptive motor learning
Irina Scheer, Mario Prsa · FENS Forum 2024
Sensorimotor adaptation, crucial for refining movements in response to unexpected errors, fundamentally depends on the cerebellum. The olivary climbing fiber (CF) input to cerebellar Purkinje cells (PC) acts as a “teacher” signal during motor learning and drives cerebellar plasticity. Although the CF input reliably evokes PC dendritic spikes, it is not the only signal that modulates this post-synaptic response. To disentangle the modulation of the pre-synaptic CF burst from that of its post-synaptic PC dendritic response, we simultaneously imaged PC dendrites and CF terminals with 2-photon mic
ePoster · Neuroscience