Role of perineuronal nets in the frontal cortex in compulsive rats selected by schedule-induced polydipsia
Elena Martín-González, Manuela Olmedo-Córdoba, Ángeles Prados-Pardo, Santiago Mora, Aitor Sanchez-Hernandez, Patricia Ibáñez-Marín, Margarita Moreno-Montoya, Marta Miquel · FENS Forum 2024
Compulsive behavior, observed in several neuropsychopathological disorders, reflects a deficiency in inhibitory control. This inability to cease actions is associated with abnormal activation and plasticity in the Frontal Cortex (FC). Perineuronal nets (PNNs), which enwrap the cell-body and proximal dendrites of neurons, have been proposed as a candidate mechanism for modulating neuroplasticity. We investigated the changes in activation (cFos expression) and in plasticity (PNN expression) in different regions of the FC through immunolabeling and confocal microscopy in rats selected as high or
ePoster · Neuroscience