Insights into the pharmacology of GluN3A receptors: Exploring the mechanism of action of selective inhibitors and their activity at native receptors
Anne-Kathrin Ludwig, Jadranka Hillebrecht, Sandra Fischer, Julian Klepp, Moritz von Heimendahl, Daniel Ursu · FENS Forum 2024
N-Methyl-D-aspartate receptors (NMDAR), a class of ionotropic glutamate receptors, play a critical role in synaptic transmission and plasticity in the central nervous system. A unique subtype of these receptors, GluN1/3A, predominantly expressed during early brain development, has been recently proposed as an excitatory glycine receptor. Our investigation aims to deliver a comprehensive characterization of the mechanism of action of recently reported selective GluN3A inhibitors by using a stable cell line expressing recombinant GluN1/3A receptors. Furthermore, we are describing an assay for ev
ePoster · Neuroscience