Topic: Channelrhodopsin 2

Recent data show that a significant fraction of cortical pyramidal neurons has an axon originating from a basal dendrite (axon-carrying dendrite, AcD) rather than from the soma. In the rodent hippocampus, these AcD cells convey privileged synaptic excitation especially in network states with strong perisomatic inhibition (Hodapp et al., 2022). We have recently shown that hippocampal AcD cells receive stronger commissural input than neurons with somatic axon origin (non-AcD) (Stevens et al., 2023).AcD cells are also present in the neocortex, though seemingly less frequent than in the hippocampu