Cerebrospinal fluid-contacting neurones are functionally connected to cardinal motor interneurons in the mice spinal cord
Edith Blasco, Caroline Michelle, Nicolas Wanaverbecq · FENS Forum 2024
To position his feet correctly on the wire, tightrope walker needs precise sensory feedback. This skilled motor behaviour requires the rapid integration of external sensory input to achieve accuracy in foot placement while keeping the balance. Neurones in contact with the cerebrospinal fluid (CSF-cNs), localized around the medullo-spinal central canal in all vertebrates, are GABAergic and selectively express PKD2L1 channel (Polycystin Kidney Disease 2-like1), a member of TRP superfamily, with chemo/mechanosensitive properties. In zebrafish, CSF-cNs respond to spinal cord bending and modulat
ePoster · Neuroscience