ePoster · Neuroscience
Neuropathology of the striatum in X-linked dystonia parkinsonism
Oliver Burnett, Adelie. Y. S Tan, Christine. J Arasaratnam, N. S. S. S. Thai, Clinton Turner, R. L. M Faull, M. K Singh-Bains · FENS Forum 2024
X-linked dystonia-parkinsonism (XDP) is a recessive neurodegenerative disease endemic to Panay, Philippines. The XDP striatum is notably reported to undergo significant atrophy, neuronal loss, and astrogliosis. However, detailed neuropathological studies characterising the human XDP striatum are limited.To advance our understanding of the human XDP striatum, immunohistochemistry coupled with automated analysis was conducted on post-mortem striatal tissue from 12 XDP and 5 age-matched neurologically normal cases to detail (1) the neurochemical architecture and (2) neuronal and glial populations