Role of nicotinic acetylcholine receptors expressed by cholinergic interneurons in the control of striatal activity
Amanda Barboza, Marine Chazalon, Serge N. Schiffmann, Helena Janíčková · FENS Forum 2024
Striatum plays an important role in the control of motor functions that are dependent on a balance between striatal dopamine and acetylcholine neuromodulators. The main source of acetylcholine in the striatum are cholinergic interneurons (CINs) which express heteromeric nicotinic acetylcholine receptors (nAChRs) containing beta2 subunit (beta2* nAChRs). Our group has previously shown that the deletion of beta2* nAChRs in CINs leads to behavioural changes in mice and to alterations of Fos expression in the striatum. Therefore, we hypothesize that the beta2 deletion leads to a decrease of CINs'
ePoster · Neuroscience