Topic: chemical hypoxia model

Parkinson’s disease (PD) is the second most common neurodegenerative disease with high burden on patients, but lack of disease modifying treatment. Therefore, identification of a cause for initiation and progression of this disease are research priorities. It is widely accepted, that the pathogenic aggregation of the alpha synuclein (aSyn) protein is involved in the loss of dopaminergic neurons in PD. In this project, we aim to illuminate the influence of hypoxia on the progression and initiation of PD in a murine model with focus on inflammation. Activity and differentiation of immune cells i