Dissecting the requirements for biological repair and restoration of walking following increasingly severe spinal cord injuries at different timepoints
Alexandra de Coucy, Jordan Squair, Matthieu Gautier, Michael Skinnider, Viviana Aureli, Achilleas Laskaratos, Quentin Barraud, Alan Teo, Jocelyne Bloch, Bernard Schneider, Zhigang He, Michael Sofroniew, Gregoire Courtine, Mark Anderson · FENS Forum 2024
The clinical challenge posed by spinal cord injury (SCI) remains a significant and unresolved issue. Engineering a treatment for SCI will require biological repair interventions that restore connectivity through or around lesions. Using a combination of advanced neuroanatomical viral tract tracing, projection-specific and comparative single-nucleus RNA sequencing, bioinformatic techniques, we recently identified a molecularly defined subpopulation of excitatory projection neuron in the mid-thoracic spinal cord that extend axons to the lumbar spinal cord where walking execution centers reside.
ePoster · Neuroscience