Cannabidiol at nanomolar concentrations negatively affects signaling through the adenosine A2A receptor
Iu Raïch, Jaume Lillo, Joan Biel Rebassa, Toni Capó, Gemma Navarro, Rafael Franco · FENS Forum 2024
Cannabidiol (CBD) is a phytocannabinoid with potential as a therapy for a variety of diseases. CBD may act via cannabinoid receptors but also via other G-protein-coupled receptors (GPCRs), including the adenosine A2A receptor. Homogenous binding and signaling assays in Chinese hamster ovary (CHO) cells expressing the human version of the A2A receptor were performed to address the effect of CBD on receptor functionality. CBD was not able to compete for the binding of a SCH 442416 derivative labeled with a red emitting fluorescent probe that is a selective antagonist that binds to the orthosteri
ePoster · Neuroscience