Uncovering schizophrenia through patient iPSC-derived thalamic neurons
Marilyn M. Angulo Salavarria, Claudia Dell’Amico, Elena Rita Vecchi, Michela Giacich, Claudia Vittoria Oimeda, Francesco Luciano Donati, Anna Castelnovo, Marta Re, Eleonora Maggioni, Paolo Brambilla, Armando D’Agostino, Luciano Conti, Marco Onorati · FENS Forum 2024
The human brain is an intricate and sophisticated organ, composed of interconnected networks of neurons that collaborate to execute specific functions. Disruptions in the generation of specific networks can lead to psychiatric disorders, such as schizophrenia (SCZ), a severe neurological condition with a global prevalence of 1% and a significant genetic basis. Ongoing research indicates that SCZ-related genes influence neuronal differentiation, ultimately resulting in impaired neural circuits. Notably, various studies have identified alterations in sleep spindles as potential inheritable bioma
ePoster · Neuroscience