The role of GABAergic inputs and chloride transporters in the activation and death of different Cajal-Retzius neuron subpopulations
Federico De Rosa, Ahd Abusaada, Heiko J. Luhmann, Werner Kilb, Anne Sinning · FENS Forum 2024
Cajal-Retzius neurons (CRNs) are among the first-born neurons in the neocortex and are critically involved in cortical layering during their transient lifetime. The molecular mechanisms behind early death of CRNs are still unclear but apoptosis is regulated by neuronal activity. During early development, CRNs are embedded into immature circuits where they mostly receive GABAergic inputs. Through immunohistochemistry and high-resolution confocal imaging, we quantified GABAergic synapse localizations across cortical layers during development in early postnatal mice and compared the GABAergic pro
ePoster · Neuroscience