Frontal dynamics underlying flexible decision making in mice
Francesca Abela, Jeroen J. Bos, Francesco P. Battaglia, Paul H. E. Tiesinga, Liya Ma · FENS Forum 2024
Humans and other animals require flexibility to make decisions appropriate for an ever-changing environment. The way mammalian brains achieve flexible decision making is not fully understood. The probabilistic reversal learning (PRL) task is a powerful tool used to assess behavioral flexibility and how positive and negative feedbacks influence decision making, both in healthy subjects and in patients with a wide range of neurological conditions like Autistic Spectrum Disorder and Schizophrenia, as well as animal models. We trained C57BL/6 mice on PRL and conducted high-density single unit reco
ePoster · Neuroscience