Topic: cholinergic signalling

Imbalance of the autonomic nervous system is implicated in numerous cardiovascular pathologies. Enhanced cholinergic signalling in the heart has therapeutic potential and cholinesterase (ChE) inhibitors are under consideration for treating cardiovascular pathologies. Nevertheless, information about ChE in heart and their role in cardiac physiology are sparse. Here, we characterize the molecular composition, localization, and physiological functions of ChE in the mouse heart. Biochemical, microscopic, and physiological experiments were used to analyse ChE in mutant mice hearts lacking different