Attenuation of chondroitin 4 sulfate in the perineuronal nets of parvalbumin neurons leads to perseverance and increased social memory
Jana Svobodová Burianová, Jiří Růžička, Tereza Klausová, Jan Svoboda, Pavla Jendelová, James F. Fawcett, Jessica C. F. Kwok · FENS Forum 2024
Perineuronal nets (PNNs) are dense extracellular matrix around a subset of neurons, mostly parvalbumin neurons (PVNs), regulating plasticity. The sulfation pattern of chondroitin sulfate chains within PNNs is key to their functions. Chondroitin 4 sulfate (C4S) levels rise with brain maturation and then slowly toward late ageing. The shift toward increased C4S/C6S ratio observed at the end of critical period and ageing was proposed as the plasticity limiting factor and could potentially prevent aberrant plasticity. Knockout of chondroitin sulfotransferase 11 (Chst11), an enzyme for C4S sulfatio
ePoster · Neuroscience