Topic: chromosome 21 trisomy

Down syndrome (DS) results from chromosome 21 trisomy, causing cognitive and developmental challenges often accompanied by hearing deficits. Studies on humans using EEG and MEG have identified prolonged latencies in sound-evoked responses in DS. However, the origin and characteristics of these deficits remain unclear. This study investigates auditory processing in a DS rat model to determine whether sensory deficits arise from early processing areas, such as the auditory thalamus and primary auditory cortex (A1), or higher-level cognitive alterations. We conducted neural activity recordings, u