Topic: Chronic corticosterone administration

Major Depressive Disorder (MDD) poses a global burden, affecting over 300 million individuals and presenting a significant therapeutic challenge due to the limited efficacy of conventional antidepressants. The investigation of rapid-acting antidepressants, exemplified by ketamine, has garnered attention, yet the intricate underlying processes remain incompletely understood.This study systematically evaluated the acute effects of ketamine (10 mg/kg, i.p.) and fluoxetine (3 x 10 mg/kg, i.p.) on depression-like behavior in animal models subjected to chronic restraint stress (CRS, 6 weeks) and chr