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Topic: chronic epilepsy

Seminar
1 seminar

In Biology and Biomedical Engineering

Seminar · Clinical Neurology

Ex vivo gene therapy for epilepsy. Seizure-suppressant and neuroprotective effects of encapsulated GDNF-producing cells

Michele Simonato · Università Vita-Salute San Raffaele

Wed, Nov 4, 2020 · 16:00 UTC

A variety of pharmacological treatments exist for patients suffering from focal seizures, but systemically administered drugs offer only symptomatic relief and frequently cause unwanted side effects. Moreover, available drugs are ineffective in one third of the patients. Thus, developing more targeted and effective treatment strategies is highly warranted. Neurotrophic factors are candidates for treating epilepsy, but their development has been hampered by difficulties in achieving stable and targeted delivery of efficacious concentrations within the brain. We have developed an implantable cel