Dorsal hippocampal CA3-CA1 long-term plasticity and the effect of aerobic exercise in anaesthetised and awake sub-chronic phencyclidine rat model for schizophrenia
Ningyuan Sun, Michael Harte, John Gigg · FENS Forum 2024
Background: Hippocampal memory deficit is an important symptom in patients with schizophrenia that responds poorly to antipsychotic treatment. Here, we investigated deficits in hippocampal long-term potentiation/depotentiation changes in the sub-chronic phencyclidine (scPCP) rat model for schizophrenia and how chronic exercise as a non-pharmacological treatment may produce hippocampal synaptic and cognitive improvements.Methods: 60 Female Lister Hooded rats (50 for acute recording and 10 for chronic recording) were dosed with either saline or PCP (2 mg/kg, i.p.) twice daily for seven days foll
ePoster · Neuroscience