Hippocampal plasticity in the Wistar-Kyoto rat: Effects of chronic mild stress, acute and chronic ketamine treatment
Vincent Loizeau, Sylvain Hugel, Robin Kuster, Alexandra Barbelivien, Lucas Lecourtier · FENS Forum 2024
Depression affects 20% of the general population and is a leading cause of disability worldwide, with one third of patients presenting treatment-resistant depression (TRD). Subanesthetic ketamine is a promising rapid-acting TRD pharmacotherapy, but optimal treatment frequency remains unclear. The present study aims to better understand the effects of an acute (single dose) and chronic (one week daily) 10mg/kg ketamine treatment on hippocampal plasticity, a key mechanism impaired in depression, in a putative TRD model: the Wistar-Kyoto (WKY) rat exposed to chronic mild stress (CMS). Rats were e
ePoster · Neuroscience