Microglial activation in the anterior cingulate cortex: A biological marker of early adverse events and future vulnerability to develop alcohol use disorder
Léa Aeschlimann, Narimane Bouzourène, Valentin Zufferey, Kevin Richetin, Boutrel Benjamin · FENS Forum 2024
Epidemiological studies have long acknowledged that only a minority of the population is at risk of losing control over alcohol consumption. Aiming at identifying the roots of this vulnerability, ongoing evidence from our laboratory revealed a significant vulnerability to lose control over alcohol consumption in male Wistar rats subjected to a chronic mild unpredictable stress (CMUS) during adolescence. This excessive alcohol seeking behaviour correlated with significant changes in the gut microbiota composition. Most importantly, Fecal Microbiota Transplantation (FMT) from resilient to vulner
ePoster · Neuroscience