Topic: chronic musculoskeletal pain

The placebo and nocebo effects highlight the importance of expectations in modulating pain perception. Yet, we don't need an external source of information to form expectations about pain. The brain can learn to predict pain in a more fundamental way, simply by experiencing fluctuating, non-random streams of noxious inputs, and extracting their temporal regularities. This process is called statistical learning. Here we address two key open questions: (1) does statistical learning modulate pain perception? and (2) is it affected in people with chronic musculoskeletal pain? In a first experiment