Topic: chronic social conflict

Aggression, leading to the formation of social hierarchy, has an evolutionary role in reducing conflict and facilitating the allocation of limited resources. Previous studies in mice have identified the regions involved in the neural circuitry of aggression, yet the mechanisms leading to the emergence of aggressive behavior remain to be poorly understood. To analyze such mechanisms, we used a mouse chronic social conflict paradigm where multiple aggressive phenotypes were formed, for which we obtained behavioral readouts (134 mice) and whole-brain snapshots of neuronal activity (c-Fos; 54 mice