Chronic unpredictable sleep disruption induces changes in locomotor activity, metabolism, and inflammation in Wistar rats
Heather Macpherson, Roger Varela, Sebastian McCullough, Tristan Houghton, Isha Chawla, Ning Wang, Xiaoying Cui, Susannah Tye · FENS Forum 2024
Stress and sleep disruption promote inflammation and metabolic adaptations, with important disease-modifying implications for psychiatric disorders. Using a novel chronic unpredictable sleep disruption (CUSD) paradigm, we characterised the impact of disrupted sleep and/or stress hormone exposure on locomotor behaviour and central markers of inflammation in the nucleus accumbens (NAc), a region implicated in regulation of mood, motivation and locomotor activity. Forty-eight Wistar rats (24 male; 24 female) were separated into groups exposed to combinations of CUSD/non-CUSD and corticosterone (2
ePoster · Neuroscience