Topic: chronotherapeutic treatment

Circadian rhythms are ~24-hour oscillations that provide temporal integration of physiology and behavior that are entrained to the earth’s light-dark cycle via photic input to the suprachiasmatic nuclei (SCN). The SCN (i.e., central clock), sets central and peripheral clocks accordingly to maintain proper synchronization with the external solar day. Exposure to artificial light at night (ALAN) resets the SCN, disrupting daily internal rhythms. Our lab and others have demonstrated daily rhythms in transcellular permeability via efflux mediated transport at the blood-brain barrier (BBB). However