The transient receptor potential melastatin subtype 8 (TRPM8) channel is inhibited by the prostacyclin receptor in a Gq/11-dependent manner
Cosmin Trif, Alexandra Banica, Alexandra Manolache, Sorina Andreea Anghel, Debora Hutanu, Teodora Stratulat, Rodica Badea, George Oprita, Tudor Selescu, Stefana Petrescu, Marco Sisignano, Stefan Offermanns, Alexandru Babes, Sorin Tunaru · FENS Forum 2024
The Transient receptor Receptor potential Potential melastatin Melastatin family member subtype 8 (TRPM8) receptor-channel is involved in mammalian innocuous cold perception and is also known to mediate anti-inflammatory effects, reversing nociceptive hypersensitivity and reducing chronic pain. Besides the well-characterized effects of prostacyclin (PGI2) in the vasculature, there is a general recognition that PGI2 is also involved in nociception, as it induces pain sensitivity and increase inflammatory responses. These biological effects are mediated by the prostacyclin receptor (IP-R) expres
ePoster · Neuroscience