Visual thalamus adaptive response to imbalanced sensory input: Decrypting molecular mechanisms in amblyopia
Béatrice Marquèze-Pouey, Maya Belghazi, Cécile Iborra, Laure Molinières, Aurore Aziz, Michael Russier, Dominique Debanne · FENS Forum 2024
Amblyopia arises from neuronal adaptation due to abnormal experience of one eye during a critical period of visual development. The molecular mechanisms underlying amblyopia are not characterized. To investigate this process, we used the monocular deprivation experimental paradigm in young rats to induce plasticity of neuronal excitability in dorsal lateral geniculate nucleus (dLGN) neurons (Duménieu et al., BioRxiv 2023). Employing a proteomic approach, we identified activity-dependent dynamic change in the components of dLGN neurons. By microdissection we isolated deprived and spared regions
ePoster · Neuroscience