Topic: circulating microRNAs

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder leading to age-associated dementia. For the first time in the last 20 years causative therapeutic strategies are on the horizon. However, since changes in cognitive function develop slowly over time in these patients, they are often diagnosed at an advanced stage of molecular pathology, a time point when causative treatments fail. Thus, there is great need for the identification of inexpensive and minimal invasive approaches that could be used for screening with the aim to identify individuals at risk for cognitive decline th