Brain-penetrating nanobodies illustrate routes for delivering biologics to the brain
Mireille Elodie Tsitokana, Séverine Diem, Pierre Prieu-Serandon, Chrystel Lafont, Yann Dromard, Patrice Mollard, Jean-Pierre Pouget, Jean-Philippe Pin, Laurent Prézeau, Philippe Rondard · FENS Forum 2024
Monoclonal antibodies are commonly used as a treatment for a variety of diseases, but very few are used to treat neurological conditions. One reason is that their delivery into the brain is hampered by the blood-brain barrier. Small antibody fragment from camelids, called Nanobody®, are good alternative to these conventional antibodies. In the present work, we study how brain-penetrating nanobodies reach the brain after peripheral administration in mice by developping different approaches. We used nanobodies specific to a metabotropic glutamate (mGlu) receptor, the mGlu2 subtype, as a model. F
ePoster · Neuroscience