Cisterna magna infusion of β-amyloid antibody reduces Alzheimer's disease pathology in mouse models
Gehua Wen, Nils Lindblom, Emma Nyberg, Asgeir Kobro-Flatmoen, Tomas Roo, Gunnar Gouras · FENS Forum 2024
Immunotherapy has shown promise in improving cognitive impairments in Alzheimer’s disease (AD) patients. However, further research is needed to explore target optimization and enhance the effective delivery of antibodies into the brain parenchyma. In this study, we aimed to explore methods for enhancing the efficiency of antibody entry into the brain parenchyma via cisterna magna injection to reduce plaque formation and decrease the levels of Aβ42 within hippocampal neurons. We employed intraperitoneal injection of 1M hypertonic saline to augment the delivery of antibodies in the cerebrospinal
ePoster · Neuroscience