Unraveling the roles of oligodendrocyte progenitor cells in the development of the cortical inhibitory system
Maryam Khastkhodaei Ardakani, Martino Bonato, Anna Incerti Tinterri, Niccolò Di Cintio, Ferdinando Di Cunto, Francesco Ferrini, Annalisa Buffo, Enrica Boda · FENS Forum 2024
Recent studies have revealed an unexpected contribution of oligodendroglial cells to inhibitory circuit establishment and function. Yet, the entire spectrum of oligodendroglia-interneuron interactions as well as the impact of oligodendroglia loss or dysfunction on the development of the inhibitory system are still open issues.Here, we exploited two mouse models where the germinal or the oligodendroglia-specific deletion of citron kinase (i.e. Cit-k KO or Sox10Cre::Cit-k fl/fl mice) leads to the selective ablation of cortical oligodendrocyte progenitor cells (OPCs) during the first two weeks of
ePoster · Neuroscience